All Therapeutic Products

 
Title Link
Ip-health -- Discussions of Intellectual Property and Health Care http://lists.essential.org/mailman/listinfo/ip-health 
The New England Journal of Medicine - registration for full text of Original and Special Articles six months after publication and to receive the Table of Contents by e-mail. https://secure.mms.org/custserv/single_signin.asp?productcode=toc 
FDA - CDER - subscribe to mailing lists free of charge. http://www.fda.gov/cder/cdernew/listserv.html 
AMNews e-mail alert service - offers our online readers free e-mail notification of each week's content as it is posted to our Web site. http://www.ama-assn.org/public/journals/amnews/amnalert.htm  
E-Mail Alert Service - "JAMA and Archives Journals offer free tables of contents from JAMA, the Archives Journals, and news listings from American Medical News via e-mail" http://www.ama-assn.org/public/journals/tocalert.htm 
The Scientist - "Registration is required to view our online articles. Registration is FREE" http://www.the-scientist.com/register.htm 
Annals of Internal Medicine - "Sign up below and we will e-mail you the Table of Contents for each issue on the day of publication" http://www.annals.org/shared/ealert_regtoc.html 
Public Citizen - The Health Research Group - "Keep up with Public Citizen through your E-mail!" http://www.citizen.org/hrg/ 
Kaisernetwork.org - E-mail alert http://www.kaisernetwork.org/email_alert/email.cfm 
The Economics of TB Drug Development - Global Alliance for TB Drug Development - October 2001 - (168 pages) http://www.tballiance.org/3_per.cfm?rm=economics&sub=per 
FDA -(proposed) Pediatric Rule - Regulations Requiring Manufacturers to Assess the Safety and Effectiveness of New Drugs and Biological Products in Pediatric Patients - 21 CFR Parts 201, 312, 314, and 601 - (99 pages) http://www.fda.gov/cder/guidance/pedrule.pdf 
US. District Court for the District of Columbia - Memorandum and opinion -October 25, 2001 - (24 pages) http://www.cei.org/pdfs/pediatric-ruling.pdf 
Kurt R. Karst - Comments Pediatric Testing of Prescription Drugs: the Food and Drug Administration's Carrot and Stick for the Pharmaceutical Industry - American University Law Review Vol. 49:739 - 2000 - (34 pages) http://www.wcl.american.edu/journal/lawrev/49/karst.pdf 
Public Citizen - Patently Offensive Congress Set to Extend Monopoly Patents for Cipro and Other Drugs - November 2001 - (20 pages) http://www.citizen.org/documents/ACF34F.PDF 
Pediatric Trials and Intellectual Property Incentives in the EU - A Report by Europe Economics for Merck Sharp and Dohme (Europe) Inc. - May 2001 - (73 pages) http://www.eer.co.uk/download/eepaedia.pdf 
U.S. Department of Health and Human Services - Pediatric Advisory Subommittee Ethical Issues Day 1 - November 15, 1999 - (291 pages) http://www.medicigroup.com/resources/Resources-Ethics%20&%20Patient%20Recruitment.pdf 
Marie Abbet - Cobayes Humains - L'insoutenable légèreté de nos autorités - l'Hebdo - 3 juin 1999 http://www.webdo.ch/hebdo/hebdo_1999/hebdo_22/cobaye_22.html  
Béatrice Schaad - Cobayes Humains - La Suisse importe des cobayes humains - l'Hebdo - 12 mai 1999 http://www.webdo.ch/hebdo/hebdo_1999/hebdo_20/dossier_intro_20.html 
Marie Abbet - Cobayes Humains - La chimie bâloise paiera-t-elle le prix de la honte? - L'Hebdo - 1er juillet 1999 http://www.webdo.ch/hebdo/hebdo_1999/hebdo_26/cobayes_26.html 
Swissmedic Journal 1/2002 (32 pages) http://www.swissmedic.ch/files/pdf/01_2002.pdf
Swissmedic - home page (english) http://www.swissmedic.ch/?lang=2
Jean-Louis Duc, Professeur UNIL - Quelques réflexions en rapport avec la dispensation des médicaments à la lumière de l'exemple vaudois - (21 pages) http://www.unil.ch/droit/publ_jld/Medicaments.pdf
Importations parallèles et droit des brevets Rapport du Conseil fédéral du 8 mai 2000 en réponse à la question de la Commission de l'économie et des redevances du Conseil national (CER) du 24 janvier 2000 - (from page 38) http://www.evd.admin.ch/dynamic/dm/LOI_SUR_LES_CARTELS/F/MESSAGE/Message_relatif_a_la_revision_de_la_loi_sur_les%20cartels.pdf
AMEX Pharmaceutical Index http://www.amex.com/asp/option_chain.asp?symbol=DRG&selected=DRG
RxList - The Top 200 Prescriptions* for 2000 by Number of US Prescriptions Dispensed Generic name link leads to Drug Monograph information where available. http://www.rxlist.com/top200.htm
Pfizer SEC filings with SEC http://www.edgar-online.com/brand/yahoo/search/?sym=PFE
J.C. Dumon, M. Sneyers et W. Moens - Report: First Gene Therapy Related Death - Belgian Biosafety Council - 2000 - (20 pages) http://biosafety.ihe.be/GT/regulatory/RapportEN27_06_2001.pdf
Gene Therapy Advisory Committee - Health Departments of the United Kingdom - 1999 - (58 pages) http://www.doh.gov.uk/genetics/gtac6.pdf
IHGT -Insitute for Human Gene Therapy - University of Pennsylvania - More information on OTC Deficiency and the Clinical Trial http://www.uphs.upenn.edu/ihgt/otcinfo.html
Association of American Medical Colleges - Protecting Subjects, Preserving Trust, Promoting Progress– Policy and Guidelines for the Oversight of Individual Financial Interests in Human Subjects Research - December 2001 - (25 pages) http://www.aamc.org/members/coitf/firstreport.pdf
Report of Independent Panel Reviewing the University of Pennsylvania's Institute for Human Gene Therapy http://www.upenn.edu/almanac/v46/n34/IHGT-review.html
Action by the University of Pennsylvania in Response to the "Report of the Independent Panel Reviewing the Institute for Human Gene Therapy" http://www.upenn.edu/almanac/v46/n34/OR-IHGT-actions.html
FDA - Warning Letter of March 3, 2000 to the University of Pennsylvania in relation with the death of Jesse Gelsinger during a clinical trial http://www.fda.gov/foi/warning_letters/m3435n.pdf
University of Pennsylvania - ORA web site home page - regulatory affairs http://www.upenn.edu/regulatoryaffairs/
USPTO - Patenting By Geographic Region (State and Country), Breakout by Technology Class Count of 1996 - 2000 Utility Patent Grants By Calendar Year of Grant http://www.uspto.gov/web/offices/ac/ido/oeip/taf/clsstc/regions.htm
Institute of Medicine - Small Clinical Trials: issues and challenges - 2001 http://books.nap.edu/books/0309073332/html/R1.html#pagetop
Philippe Ducor - Coauthorship and Coinventorship - Science Magazine - Volume 289, Number 5481, Issue of 11 Aug 2000, pp. 873-875. http://watson.fapesp.br/nuplitec/873.html
Uniform Requirements for Manuscripts Submitted to Biomedical Journals - Updated May 1999 http://www.acponline.org/journals/annals/01jan97/unifreqr.htm
Biotechnology, Ethics and Government: Report to the Interdepartmental Working Group on Ethics - Winter 1998 - (125 pages) http://strategis.ic.gc.ca/pics/bh/bioteche.pdf
Anna E. Morrison - The U.S. PTO's New Utility Guidelines: Will They Be Enough to Secure Gene Patent Rights? - 1 J. MARSHALL REV. INTELL. PROP. L. 142 - 2001 - (22 pages) http://www.jmls.edu/ripl/vol1/issue1/morrison.pdf
Lawrence M. Sung - Part II: Judicial Issues Stranger In A Strange Land: Biotechnology and the Federal Circuit - 168 Re-Engineering Patent Law Vol. 2:167- (32 pages) http://law.wustl.edu/Journal/2/p167sung.pdf
Sherry M. Knowles - Written Description and Enablement Requirements for Pharmaceutical, Chemical and Biotechnology Inventions - (36 pages) http://www.kslaw.com/library/pdf/pharmaknowles.pdf
Matthew D. Kellam - Making Sense out of Antisense: The Enablement Requirement in Biotechnology After Enzo Biochem v. Calgene - 222 INDIANA LAW JOURNAL [Vol. 76:221 - (22 pages) http://www.law.indiana.edu/ilj/v76/no1/kellam.pdf
Carlos Correa- Integrating Public Health Concerns into Patent Legislation in Developing Countries - South Centre - 2000 (143 pages) http://www.southcentre.org/publications/publichealth/publichealth.pdf
Arti Kaur Rai - Regulating Scientific Research: Intellectual Property Rights and the Norms of Science - Nortwestern University Law Review - 1999 - (76 pages) http://www.acusd.edu/~arai/raifinal.pdf
DeAngelis CD. Conflict of interest and the public trust. JAMA. 2000;284:2237-2238 http://jama.ama-assn.org/issues/v284n17/fpdf/jed00080.pdf
Keith E. Maskus - Parallel Imports in Pharmaceuticals: Implications for Competition and Prices in Developing Countries - Final Report to WIPO - April 2001 - (85 pages) http://www.wipo.int/about-ip/en/studies/pdf/ssa_maskus_pi.pdf
Christopher Heath - Parallel Imports and International Trade - WIPO - (12 pages) http://www.wipo.org/sme/en/documents/pdf/atrip_gva_99_6.pdf
Mattias Ganslandt and Keith E. Maskus - Parallel Imports of Pharmaceutical Products in the European Union - Please do not quote without permission - (27 pages) http://econ.worldbank.org/files/2240_wps2630.pdf
Mattias Ganslandt and Keith E. Maskus - Parallel Imports of Pharmaceutical Products in the European Union - The Research Institute of Industrial Economics - Working Paper No. 546, 2001 - (28 pages) http://swopec.hhs.se/iuiwop/papers/iuiwop0546.pdf
K Balasubramaniam - Equitable Pricing, Affordability and Access to Essential Drugs in Developing Countries: Consumers Perspective - WTO - (12 pages) http://www.wto.org/english/tratop_e/trips_e/hosbjor_presentations_e/35balasubramaniam_e.pdf
Leu Investment Research - Sector Report: Pharmaceuticals Europe – Hopes Focus on Biotechnology - December 2001 - (57 pages) http://www.leu.ch/pdf/pharma_en.pdf
TRIPS on Trial - The Impact of WTO’s Patent Regime The Impact of WTO’s Patent Regime On the World’s Farmers, the Poor On the World’s Farmers, the Poor and Developing Countries and Developing Countries -Declaration de Berne September 2001 - (27 pages) http://www.evb.ch/cm_data/tripsontrial.PDF
François Dessemontet - L’épuisement en droit des brevets : un arrêt de principe - CEDIDAC Bulletin d’information n° 32 – Décembre 1999 - (9 pages) http://www.unil.ch/cedidac/bulletin/bulletin_32.pdf
Conseil national - Motion CSEC-CN (00.455). Autorisation du diagnostic préimplantatoire lors de risque grave - March 20, 2002 http://www.parlament.ch/ab/frameset/f/n/4612/55916/f_n_4612_55916_55939.htm
WHO - Lignes Directrices Opérationnelles pour les Comités d’Ethique chargés de l’évaluation de la Recherche Biomédicale - 2000 - (19 pages) http://www.who.int/tdr/publications/publications/pdf/ethicsfr.pdf
H. Peter Steeves - “Start a Line and Get Me a Consent Waiver, STAT!” Autonomy, Community Consultation, and Informed Consent in Emergency Research - (54 pages) http://www.ars-rhetorica.net/Queen/VolumeSpecialIssue/Articles/Steeves.pdf
Lausanne University - Règlement de la Commission Permanente d'Ethique de la Recherche Clinique - (6 pages) http://www.unil.ch/cercfm/docs/Regl_cercfm_2000.pdf
Lausanne University - Recommandations pour la rédaction d'un protocole de recherche soumis à la Commission d'Ethique de la Recherche clinique de la Faculté de Médecine http://www.unil.ch/cercfm/recommandations.html
Lausanne University - Exemple de formulaire de consentement éclairé (consentement écrit) http://www.unil.ch/cercfm/formulaire.html
Lausanne University - Demande d’évaluation de l’essai clinique: http://www.unil.ch/cercfm/docs/SoumissionLS.dot.pdf
Swiss Ethics Committee on Non-human Gene Technology Avis relatif au projet de loi fédérale sur la transplantation d'organes, de tissus et de cellules (loi sur la transplantation, LTx) mis en consultation - (11 pages) http://www.buwal.ch/stobobio/ekah/pdf/280200f.pdf
Académie Suisse des Sciences Médicales Directives pour la recherche expérimentale sur l’être humain - (16 pages) http://www.samw.ch/content/Richtlinien/f_Forschungsunters.pdf
Helsinki Declaration - World Medical Association - Ethical Principles for Medical Research Involving Human Subjects - last amendment 52nd WMA General Assembly, Edinburgh, Scotland, October 2000 - (5 pages) http://www.wma.net/e/policy/17c.pdf
Title 21--Food and Drugs Chapter I - - Part 50--Protection of Human Subjects http://www.access.gpo.gov/nara/cfr/waisidx_00/21cfr50_00.html
Title 21--Food and Drugs Chapter I-- Part 56--Institutional Review Boards http://www.access.gpo.gov/nara/cfr/waisidx_00/21cfr56_00.html
The Belmont Report - Ethical Principles and Guidelines for the Protection of Human Subjects of Research - April 18, 1979 http://ohsr.od.nih.gov/mpa/belmont.php3
US - Title 45 CFR Part 46 - Protection Of Human Subjects http://ohsr.od.nih.gov/mpa/45cfr46.php3
Guidelines for the Conduct of Research Involving Human Subjects at the National Institutes of Health http://ohsr.od.nih.gov/guidelines.php3
IRB Protocol Review Standards - Minimal regulatory requirements for IRB review, discussion and documentation in the meeting minutes http://ohsr.od.nih.gov/info/checklist_IRB_protocol.html
IRB - OHSR Information Sheets http://ohsr.od.nih.gov/info/
WTO - Ministerial Declaration - Adopted on 14 November 2001 - (10 pages) http://www.wto.org/english/thewto_e/minist_e/min01_e/mindecl_e.pdf
WTO -Declaration on the TRIPS Agreement and Public Health - Adopted on 14 November 2001 - (2 pages) http://www.wto.org/english/thewto_e/minist_e/min01_e/mindecl_trips_e.pdf
WTO - Implementation-Related Issues and Concerns - Decision of 14 November 2001 - (8 pages) http://www.wto.org/english/thewto_e/minist_e/min01_e/mindecl_implementation_e.pdf
FTC - In the Matter of 180-Day Generic Drug Exclusivity for Abbreviated New Drug Applications - Comment of the Staff of the Bureau of Competition and of Policy Planning of the FTC - November 4, 1999 http://www.ftc.gov/be/v990016.htm
Swissmedic - Formulaire de base pour la soumission d'un projet de recherche biomédicale http://www.swissmedic.ch/files/pdf/f_FormEKAntrag.doc
Swissmedic - Formulaire d'avis de la Commission d'éthique de la recherche http://www.swissmedic.ch/files/pdf/f_FormEKBeschluss.doc
Swissmedic - Formulaire de notification pour les essais cliniques de médicaments http://www.swissmedic.ch/files/pdf/B3.1.121_Formulair_de_notification_pour_les_essais_cliniques_de_m%E9dicaments.dot
Swissmedic - list of ethics committee http://www.swissmedic.ch/files/pdf/Liste_Ethikkommissionen-f.pdf
Swissmedic - Commentaires concernant le formulaire «Demande d’autorisation / modification» http://www.swissmedic.ch/files/pdf/Commentaires%20sur%20le%20formulaire%20demande%20d%27autorisation%20-%20modification.pdf
OClin - Federal Ordinance on clinical trials http://www.admin.ch/ch/f/rs/8/812.214.2.fr.pdf
Hippocratic Oath -- Modern Version http://www.pbs.org/wgbh/nova/doctors/oath_modern.html
ASSM - Commission centrale d’éthique Rapport annuel 2000 http://www.samw.ch/content/Kommissionen/fk_ZEK.htm#Rapport annuel
Préposé fédéral à la protection des données - Guide relatif au traitement de données personnelles dans le domaine médical - (53 pages) http://www.edsb.ch/f/doku/leitfaeden/medizin.pdf
Conseil de l'Europe Comité des Ministres Recommandation No R(90)3 du Comité des Ministres aux Etats membres sur la recherche médicale sur l'être humain adoptée par le Comité des Ministres le 6 février 1990 http://www.inserm.fr/ethique/Ethique.nsf/397fe8563d75f39bc12563f60028ec43/325e8f4b601fa154c125675400383408?OpenDocument
COMITE DIRECTEUR POUR LA BIOETHIQUE (CDBI) - Développement dans le domaine de la bioéthique dans les Etats membres,
dans les autres Etats et dans les organisations internationales - Strasbourg, le 26 Octobre 2001 - (83 pages)
http://www.legal.coe.int/bioethics/pdf/CDBI-INF(2001)6F.pdf
The Danish Council of Ehtics - Genetic investigation of Healthy Subjects - Report on Presymptomatic Gene Diagnosis http://www.etiskraad.dk/publikationer/genetic/ren.htm
HGC and the Human Fertilisation Embryology Authority (HFEA) - Outcome of the Public Consultation on Preimplantation Genetic Diagnosis - (33 pages) http://www.hgc.gov.uk/business_publications_pgdoutcome.pdf
Human Genetics Commission - First Annual Report- (58 pages) http://www.hgc.gov.uk/business_publications_annualreport_first.pdf
CIOMS - International Ethical Guidelines for Biomedical Research Involving Human Subjects - Revised draft, January 2002 http://www.cioms.ch/frame_guidelines_january_2002.htm
CIOMS - The Declaration of Inuyama - Human Genome Mapping, Genetic Screening and Gene Therapy http://www.cioms.ch/frame_1990_texts_of_guidelines.htm
CIOMS - International Guiding Principles for Biomedical Research Involving Animals (1985) http://www.cioms.ch/frame_1985_texts_of_guidelines.htm
Global Forum for Health Research - home page - "to help correct the 10/90 gap by focusing research efforts on diseases representing the heaviest burden on the world's health " http://www.globalforumhealth.org/pages/index.asp
Global Forum for Health Research - Monitoring Financial Flows for Health Research (publication of 5 chapters) http://www.globalforumhealth.org/FilesUpld/20.pdf
Global Forum for Health Research - The 10/90 Report on Health Research 2000 - (publication of 7 chapters) http://www.globalforumhealth.org/non_compliant_pages/report00/00intro.pdf
ICSU - International Council for Science - home page - "a non-governmental organization, founded in 1931 to bring together natural scientists in international scientific endeavour http://www.icsu.org/
DIA - Drug Information Journal - freely available except for the 2 most recent years http://www.diahome.org/docs/multiLang/DIAJournal_index.cfm?PageID=dijindex
EFGCP - International Guidelines on Bioethics Informal Listing of Selected International Codes, Declarations, Guidelines, etc. on Medical Ethics/Bioethics/Health Care Ethics/Human Rights Aspects of Health - 3rd Edition - (18 pages) http://www.efgcp.org/webdocs/international.pdf
EFGCP - Optional Guideline for Good Clinical Practice Compliance and Quality Systems Auditing In conformity with the Note for Guidance on GCP CPMP/ICH/135/95 (ICH GCP) http://www.efgcp.org/webdocs/engage.pdf
EFGCP - Guidelines and Recommendations for European Ethics Committees - (18 pages) http://www.efgcp.org/webdocs/efgcprecommendation.pdf
EFGCP - Audit Working Party The handling of Case Report Form (CRF) at an investigational site http://www.efgcp.org/webdocs/handling_of_CRF.pdf
EFGCP - Audit Working Party Protocol Compliance - (6 pages) http://www.efgcp.org/webdocs/protocol_compliance.pdf
EFGCP - Records Management and Archiving Working Party Guidelines for Retention of Clinical Trial Records at Investigator Study Sites - / pages) http://www.efgcp.org/webdocs/guidelines_for_retention.pdf
EU - Directive 2001/20/EC relating to the implementation of good clinical practice in the conduct of clinical trials on medicinal products for human use http://www.efgcp.org/webdocs/guidelines_for_retention.pdf
SIDCDER - home page - "an independent international cooperative project designed to facilitate the development of the ethical review of biomedical research" http://www.sidcer.net/
The British Medical Journal - home page - access to full-text papers http://bmj.com/
The Lancet - home page - http://www.thelancet.com/journal
Nature - home page http://www.nature.com/nature/
Rika Onishi Mortimer - Demand for Prescription Drugs: The Effects of Managed Care Pharmacy Benefits - (57 pages) http://econwpa.wustl.edu:8089/eps/hew/papers/9802/9802002.pdf
Anna Merino-Castelló - The impact of the reference price system on the pharmaceutical market: a theoretical approach- February, 2000 - (32 pages) http://www.econ.upf.es/deehome/what/wpapers/postscripts/524.pdf
Gray, Sidney Skogsvik, Kenth - The Valuation Relevance of Voluntary Disclosures: A Comparative Analysis of the Disclosure Behaviour of Major Pharmaceutical Companies in Sweden and the UK - (25 pag http://www.econ.upf.es/deehome/what/wpapers/postscripts/524.pdf
Gregory S. Crawford and Matthew Shum - Uncertainty and Learning in Pharmaceutical Demand - February 2000 - (42 pages) ftp://ftp.econ.duke.edu/pub/gsc/match.pdf
Gregory Crawford Matthew Shum - State Dependence in Pharmaceutical Prescription Choice: Implications for Physician Authority and Market Structure - 1998 - (19 pages) ftp://ftp.econ.duke.edu/pub/gsc/habit.pdf
Elli Malki - Intellectual property and the valuation of biotechnology companies: GEN-dex versus Dow Jones - (11 pages) http://econwpa.wustl.edu:8089/eps/fin/papers/9709/9709002.pdf
Andreas Pyka and Paolo Saviotti - Innovation Networks in the Biotechnology-Based Sectors - July 2001 - (35 pages) http://www.wiwi.uni-augsburg.de/vwl/institut/paper/205.pdf
US - 106TH Congress 1ST Session H. R. 626 - "Health Care Research and Development and Taxpayer Protection Act’’ http://frwebgate.access.gpo.gov/cgi-bin/getdoc.cgi?dbname=106_cong_bills&docid=f:h626ih.txt.pdf
Thomas Aronsson Mats A. Bergman and Niklas Rudholm - The Impact of Generic Competition on Brand Name Market Shares: Evidence from Micro Data- December 1997 - (22 pages) http://swopec.hhs.se/hastef/papers/hastef0274.pdf
CPTECH - Frequently Asked Questions About HR 626, the `Health Care Research and Development and Taxpayer Protection Act' http://www.cptech.org/ip/health/econ/rp-faq.html
Guillem López-Casasnovas Jaume Puig-Junoy - Review of the Literature on Reference Pricing - April 14th, 2000 - (47 pages) http://www.econ.upf.es/deehome/what/wpapers/postscripts/362.pdf
WHO WTO - Report of the Workship on differential pricing and financing of essential Drug - April 2001 - (27 pages) http://www.who.int/medicines/library/edm_general/who-wto-hosbjor/wholereporthosbjorworkshop-fin-eng.pdf
S. Jacobzone - Pharmaceutical Policies on OECD Countries : Reconciling Social and Industrial Goals - Labour Market and Social Policy - Occasional Papers No. 40 - (100 pages) http://www.olis.oecd.org/OLIS/2000DOC.NSF/c5ce8ffa41835d64c125685d005300b0/c125685b0057c558c12568c400331a1e/$FILE/00075948.PDF
Kaiser Permanente - Institute for Health Policy - Existing Reporting Systems - This document provides an overview of the following existing medical care reporting systems - (20 pages) http://www.kaiserpermanente.org/medicine/ihp/pdfs/exist_error_rep.pdf
Kaiser Permanente - Institute for Health Policy - List of publications http://www.kaiserpermanente.org/medicine/ihp/publications.html
Federal Department of Justice - Explications relatives à l'ordonnance sur la procréation médicalement assistée - (6 pages) http://www.ofj.admin.ch/themen/fortpflmed/vnvo-ber-fmedv-f.pdf
Federal Department of Justice - Explications relatives à l'ordonnance sur la Commission nationale d'éthique dans le domaine de la médecine humaine - (4 pages) http://www.ofj.admin.ch/themen/fortpflmed/vnvo-ber-vnek-f.pdf
United Kingdom - Advice to Research Ethics Committees - Points to consider in ethical review of medical research involving genetic testing - October 1998 - (13 pages) http://www.doh.gov.uk/pub/docs/doh/recrev3.pdf
American Academy of Pediatrics - Guidelines for the Ethical Conduct of Studies to Evaluate Drugs in Pediatric Populations (RE9503) http://www.aap.org/policy/00655.html
FDA - Guidance for Industry - Content and format of investigational new drug applications (inds) for phase 1 studies of drugs, including wellcharacterized, therapeutic, biotechnology-derived products - (18 pages) http://www.fda.gov/cder/guidance/phase1.pdf
FDA - Guidelines for Drug Master Files - September 1989 http://www.fda.gov/cder/guidance/dmf.htm
Federal Food, Drug and Cosmetic Act - Portions revised or new- As Amended by the FDA Modernization Act of 1997 http://www.fda.gov/opacom/laws/fdcact/fdctoc.htm
ICH - Guidance for Industry E 10 Choice of Control Group and Related Issues in Clinical Trials - May 2001 - (37 pages) http://www.fda.gov/cder/guidance/4155fnl.pdf
FDA - Guidance for Industry
Acceptance of Foreign
Clinical Studies -March 2001 - (4 pages)
http://www.fda.gov/cder/guidance/fstud.pdf
FDA - Information Sheets - Guidance for Institutional Review Boards and Clinical Investigators- IRB Operations and Clinical Investigation Requirements - 1998 Update http://www.fda.gov/oc/ohrt/irbs/default.htm
EMEA - Fees payable to the EMEA - Human Medicinal Products http://www.emea.eu.int/htms/general/admin/fees/feesh.htm http://www.emea.eu.int/pdfs/general/direct/fees/711499en.pdf
EMEA - EMEA/17424/01 Position Statement on the Use of Placebo in Clinical Trials with regard to the Revised Declaration of Helsinki - June 2001 http://www.emea.eu.int/pdfs/human/press/pos/1742401en.pdf
EMEA - Market Authorisation Withdrawals (Also includes Suspensions of MA) http://www.emea.eu.int/htms/human/withdraw/withdraw.htm
EMEA - EMEA/H/30313/98 Revision 1 Procedure for Notifications of Parallel Distribution of Centrally Authorised Medicinal Products - (page 4) http://www.emea.eu.int/pdfs/human/parallel/3031398en.pdf
EMEA - CPMP Opinions on approval or refusal of marketing authorizations http://www.emea.eu.int/htms/human/opinion/opinion.htm
EMEA - CPMP/EWP/462/95 Note for Guidance on Clinical Investigation of Medicinal Products in Children (CPMP adopted March 97) - (12 pages) http://www.emea.eu.int/pdfs/human/ewp/046295en.pdf
EMEA - CPMP/EWP/240/95 Note for Guidance on Fixed Combination Medicinal Products (CPMP adopted April. 96) - (5 pages) http://www.emea.eu.int/pdfs/human/ewp/024095en.pdf
U.S. - EC MRA (Mutual Recognition Agreement) Pharmaceutical Good Manufacturing Practices Annex - Sectoral Annex for Pharmaceutical Good Manufacturing Practices GMPs) - (29 pages) http://pharmacos.eudra.org/F2/mra/doc/mraecus.pdf
U.S. - EC MRA - Joint Procedure for the Information Exchange of Serious or Life-Threatening Human / Animal Pharmaceutical Product Quality Defects and Recalls - (7 pages) http://www.emea.eu.int/pdfs/technical/mra/usa/008600en.pdf
FDA - Compliance Program Guidance Manual For FDA Staff - Compliance Program 7348.811 - Bioresearch Monitoring: Clinical Investigators http://www.fda.gov/ora/compliance_ref/bimo/7348_811/default.htm
FDA - Compliance Program 7348.810 - Bioresearch Monitoring Sponsors, Contract Research Organizations and Monitors - Date of Issuance: February 21, 2001 - Guidance for FDA Staff http://www.fda.gov/ora/compliance_ref/bimo/7348_810/default.htm
FDA - Good Laboratory Practice - GLP Final Rule - (81 pages) http://www.fda.gov/ora/compliance_ref/bimo/GLP/78fr-glpfinalrule.pdf
WHO - WHO Technical Report Series, No. 850, 1995, Annex 3 - Guidelines for good clinical practice (GCP) for trials on pharmaceutical products - (35 pages) http://www.who.int/medicines/library/par/ggcp/GCPGuidePharmatrials.pdf
WHO - General Guidelines for Methodologies on Research and Evaluation of Traditional Medicine - (80 pages) http://www.who.int/medicines/library/trm/who-edm-trm-2000-1/who-edm-trm-2000-1.pdf
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Interpharma - GfS Institut de recherche - Orientation sur la qualité et les coûts - September 24, 2001, (also http://www.interpharma.ch/themen/ghpolit/gmonitor_01/gmonitor01-pict-f.pdf) http://www.interpharma.ch/themen/ghpolit/gmonitor_01/gmonitor01-f.pdf
Interpharma, La santé publique en Suisse Prestations, coûts, prix - 2000 - (80 pages) http://www.interpharma.ch/info/wissens/gesundheit/pdf/BlauB_f00.pdf
Price of pharmaceuticals from the Swiss reimbursement list http://www.sl-preise.ch/
Tufts Center for the Study of Drug Development http://www.tufts.edu/med/csdd/index.html
Tufts Center, Outlook 2001 - (12 pages) http://www.tufts.edu/med/csdd/images/otlk2001.pdf
Tufts Center - A Methodology for Counting Costs for Pharmaceutical R&D - November 30, 2001 - (4 pages)